Defending champ Fabio Fognini crashes out in Hamburg

Serbian qualifier Filip Krajinovic defeated defending champion Fabio Fognini 6-4, 6-0 Wednesday as a host of seeded players crashed out in the second round of the Hamburg Open.

The 149th-ranked Krajinovic converted five of his 10 break point chances against the second-seeded Italian and dropped just eight points in the second set to win in only 54 minutes.

Krajinovic next plays Serbia's Dusan Lajovic, who defeated 15th-seeded Carlos Berlocq of Argentina 6-3, 6-4.

Fifth-seeded Mikhail Youzhny of Russia lost 7-5, 7-5 to 17-year-old Alexander Zverev, and another German wild card Tobias Kamke defeated 13th-seeded Argentine Federico Delbonis 6-3, 6-4. Delbonis lost to Fognini in last year's final.

Dustin Brown saved two match points in the third set before beating ninth-seeded Spaniard Fernando Verdasco 4-6, 6-2, 7-6 (8). The popular German faces Pablo Andujar of Spain in the third round.

Andujar earlier defeated Brazilian Thomaz Bellucci 6-4, 3-6, 6-2.

Leonardo Mayer of Argentina upset 10th-seeded Spaniard Guillermo Garcia-Lopez 7-6 (1), 7-6 (3) and will next play the 55th-ranked Dominic Thiem of Austria.

Lukas Rosol beat 14th-seeded Joao Sousa of Portugal 6-2, 6-4. The Czech next faces 2006 winner and third-seeded Tommy Robredo of Spain.

Fourth-seeded Alexandr Dolgopolov of Ukraine bucked the trend by beating Poland's Jerzy Janowicz 6-4, 6-1.

Also, 16th-seeded Andreas Seppi of Italy beat 2012 champion Juan Monaco of Argentina 1-6, 6-0, 7-6 (3).

Home favorite and seventh-seeded Philipp Kohlschreiber defeated Portugal's Gastao Elias 7-5, 6-1 in the late match. The German will next face 2011 champion Gilles Simon. The 12th-seeded Frenchman advanced following Martin Klizan's retirement before their match due to a left wrist injury.