Dons left waiting on injuries
Left-back Naysmith will be sent for a scan after coming off in the goalless draw against Hearts with a hamstring injury.
Milsom is still seeking specialist advice on the recurrence of a knee injury but manager Craig Brown confirmed he would be out for a "reasonable length of time".
However, midfielder Hughes could face St Mirren at Pittodrie on Saturday after responding well to treatment for a hamstring strain and Niall McGinn has returned to light training following an ankle injury.
Youngsters Clark Robertson and Jamie Masson are also back in contention following injury.