Peyton Manning drops Tom Brady 'Deflategate' joke during Rob Lowe's roast

Peyton Manning may be done playing football for a living, but that doesn't mean he's done making his opponents look foolish.

At the Comedy Central Roast of Rob Lowe on Saturday night, Manning was one of the special guests who not only made an appearance, but was also on the panel of celebrities who used the platform to roast one another, and anyone who fell within their crosshairs.

During his time on the mic, Manning rekindled the flame of an old rivalry -- the one between him and legendary New England Patriots quarterback Tom Brady -- dropping a one-liner referencing Deflategate in the middle of a joke directed towards the guest of honor, Rob Lowe.

Roast of Rob Lowe