NFL Week 16 Blazin' 5: Will Ravens cover vs. Niners on the road, Cowboys upset Dolphins?

Colin Cowherd is back with his best bets for an exciting holiday weekend of NFL action in Week 16. 

Let's get into his latest Blazin' 5. 

Seahawks (-3) @ Titans 
1 p.m. ET Sunday, CBS 

Colin's pick, score prediction: Titans +3 (Titans win 27-24)

Colin's thoughts: "[Seattle] has lost five straight road games. … that game [against Philadelphia] last week was fun, but I'm talking about a Titans defense that shut down Miami. The No. 1 red zone defense in the league is Tennessee."

Cardinals @ Bears (-4.5) 
4:25 p.m. ET Sunday, FOX and the FOX Sports app 

Colin's pick, score prediction: Cardinals +4.5 (Cardinals win 24-23) 

Colin's thoughts: "Once [the Cardinals] got Kyler Murray [back from injury], all their offensive numbers [have been] ticking up substantially. They are now a top-five red zone offense with Kyler Murray, [while] the Bears have the worst red zone defense in the league."

Cowboys @ Dolphins (-1.5)

4:25 p.m. ET Sunday, FOX and the FOX Sports app 

Colin's pick, score prediction: Cowboys +1.5 (Cowboys win 31-27)

Colin's thoughts: "[Dallas is] 9-5 against the spread. Miami's O-line is weak [while] Dallas' pass rush is excellent. The Cowboys, following a loss, have been sensational – 35-12 is their average winning score after a loss [this season] … and let's be honest, the Miami Dolphins have lost seven straight games to teams with winning records."

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Jaguars @ Buccaneers (-3)
4:05 p.m. ET Sunday, CBS 

Colin's pick, score prediction: Buccaneers -3 (Buccaneers win 28-20)

Colin's thoughts: "C.J. Beathard probably starts [at quarterback for the Jaguars], [but] Jacksonville is reeling [even with starter] Trevor Lawrence. … Baker [Mayfield's] last three games, he's been on fire [with] eight TDs [to] one pick, [and] a passer rating of 108… [Tampa Bay] is also 7-1 at home as the favorite." 

Ravens @ 49ers (-5.5)
8:15 p.m. ET Monday, ABC/ESPN

Colin's pick, score prediction: Ravens +5.5 (49ers win 28-24)

Colin's thoughts: "The Niners are going to win, but I'm taking the points at 5.5. [John] Harbaugh is a great underdog coach [and] Lamar [Jackson] is unbeatable against NFC teams and the Niners are banged up. Listen, right now, Baltimore [has] six wins against teams with a winning record, they're really good in this spot."

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