2026 NFL Odds Week 1: Lines, Spreads, Results For All 16 Games

Headlined by a Sept. 9 Super Bowl rematch between the Seahawks and Patriots, as well as the NFL’s first-ever game in Australia between the Rams and 49ers, Week 1 is absolutely loaded.

Here are the lines for every Week 1 matchup at bet365 Sportsbook as of Sept. 14. 

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

Patriots 10, Seahawks 13

Spread: Seahawks -3.5 (NE covers)
O/U: 44.5 (Under hits)

49ers 27, Rams 7

Spread: Rams -3.5 (SF covers)
O/U: 48.5 (Under hits)

Falcons 13, Steelers 20

Spread: Steelers -6.5 (PIT covers)
O/U: 40.5 (Under hits)

Ravens 41, Colts 23

Spread: Ravens -3 (BAL covers)
O/U: 48.5 (Over hits)

Bills 36, Texans 31

Spread: Bills -1.5 (BUF covers)
O/U: 44.5 (Over hits)

Bears 59, Panthers 37

Spread: Bears -3 (CHI covers)
O/U: 47.5 (Over hits)

Browns 10, Jaguars 34

Spread: Jaguars -8.5 (JAX covers)
O/U: 40.5 (Over hits)

Saints 30, Lions 31

Spread: Lions -7 (NO covers)
O/U: 49.5 (Over hits)

Jets 23, Titans 10

Spread: Titans -1.5 (NYJ covers)
O/U: 38.5 (Under hits)

Buccaneers 27, Bengals 33

Spread: Bengals -3.5 (CIN covers)
O/U: 50.5 (Over hits)

Cardinals 26, Chargers 14

Spread: Chargers -9.5 (ARI covers)
O/U: 47.5 (Under hits)

Packers 22, Vikings 39

Spread: Vikings -1.5 (MIN covers)
O/U: 46.5 (Over hits)

Dolphins 13, Raiders 27

Spread: Raiders -3 (LV covers)
O/U: 40.5 (Under hits)

Commanders 22, Eagles 24

Spread: Eagles -5.5 (WSH covers)
O/U: 44.5 (Over hits)

Cowboys @ Giants

Spread: Cowboys -3
Moneyline: Cowboys -170, Giants +145
O/U: 47.5

Broncos @ Chiefs

Spread: Chiefs -2.5
Moneyline: Chiefs -135, Broncos +115
O/U: 43.5