2025 NFL Odds Week 5: Lines, Spreads for all 14 Games

NFL Week 5 kicks off Thursday night, as the Rams host the 49ers.

Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Oct. 4.

(All times ET)

2025 NFL Week 5 Odds

THURSDAY, OCT. 2

49ERS 26, RAMS 23

Spread: Rams -8.5 (49ers cover)
Total O/U: 43.5 (Over hits)

SUNDAY, OCT. 5

VIKINGS @ BROWNS

Spread: Vikings -3.5
Moneyline: Vikings -192, Browns +160
Total O/U: 36.5

BRONCOS @ EAGLES

Spread: Eagles -4.5
Moneyline: Eagles -225, Broncos +185
Total O/U: 43.5

RAIDERS @ COLTS

Spread: Colts -7.5
Moneyline: Colts -375, Raiders +295
Total O/U: 47.5

TEXANS @ RAVENS

Spread: Texans -1.5
Moneyline: Ravens +105, Texans -125
Total O/U: 40.5

COWBOYS @ JETS

Spread: Cowboys -1.5
Moneyline: Cowboys -125, Jets +105
Total O/U: 47.5

DOLPHINS @ PANTHERS

Spread: Dolphins -1.5
Moneyline: Dolphins -118, Panthers -102
Total O/U: 45.5

GIANTS @ SAINTS

Spread: Saints -1.5
Moneyline: Giants +100, Saints -120
Total O/U: 42.5

BUCCANEERS @ SEAHAWKS

Spread: Seahawks -3.5
Moneyline: Seahawks -180, Buccaneers +150
Total O/U: 44.5

TITANS @ CARDINALS

Spread: Cardinals -7.5
Moneyline: Cardinals -425, +330
Total O/U: 41.5

LIONS @ BENGALS

Spread: Lions -10.5
Moneyline: Lions -600, Bengals +440
Total O/U: 49.5

COMMANDERS @ CHARGERS

Spread: Chargers -2.5
Moneyline: Chargers -155, Commanders +130
Total O/U: 47.5

PATRIOTS @ BILLS

Spread: Bills -8.5
Moneyline: Bills -425, Patriots +330
Total O/U: 49.5

MONDAY, OCT. 6

CHIEFS @ JAGUARS

Spread: Chiefs -3.5
Moneyline: Chiefs -185, Jaguars +154
Total O/U: 45.5

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