2025 NFL Odds Week 16: Lines, Spreads for all 16 Games
NFL Week 16 kicks off on Thursday, as the Seahawks host the Rams.
Here are the lines for every Week 16 matchup at DraftKings Sportsbook as of Dec. 21.
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THURSDAY, DEC. 18
Spread: Seahawks -1.5 (Rams cover)
O/U: 42.5 (Over hits)
SATURDAY, DEC. 20
Spread: Eagles -7.5 (Eagles cover)
O/U: 44.5 (Over hits)
Spread: Bears -1.5 (Bears cover)
O/U: 45.5 (Under hits)
SUNDAY, DEC. 21
Spread: Bills -10.5
Moneyline: Bills -625, Browns +455
O/U: 40.5
Spread: Cowboys -1.5
Moneyline: Cowboys -122, Chargers +102
O/U: 50.5
Spread: Chiefs -3.5
Moneyline: Chiefs -180, Titans +150
O/U: 37.5
Spread: Bengals -4.5
Moneyline: Bengals -218, Dolphins +180
O/U: 48.5
Spread: Saints -6.5
Moneyline: Saints -298, Jets +240
O/U: 40.5
Spread: Vikings -2.5
Moneyline: Vikings -148, Giants +124
O/U: 41.5
Spread: Buccaneers -3
Moneyline: Buccaneers -155, Panthers +130
O/U: 45.5
Spread: Broncos -3.5
Moneyline: Broncos -185, Jaguars +154
O/U: 46.5
Spread: Falcons -3
Moneyline: Falcons -155, Cardinals +130
O/U: 48.5
Spread: Lions -7.5
Moneyline: Lions -380, Steelers +300
O/U: 52.5
Spread: Texans -14.5
Moneyline: Texans -1350, Raiders +800
O/U: 39.5
Spread: Ravens -3
Moneyline: Ravens -180, Patriots +150
O/U: 48.5
MONDAY, DEC. 22
Spread: 49ers -5.5
Moneyline: 49ers -250, Colts +205
O/U: 46.5
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