2025-26 NBA Playoff Odds: Spreads, Lines for Second-Round Series

Now the NBA playoffs are in the swing of things.

Let's check out the odds for the second round of the playoffs, at DraftKings Sportsbook as of May 16.

This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports.

EAST SECOND ROUND

No. 7 PHILADELPHIA vs. No. 3 NEW YORK
NYK wins 4-0

No. 4 CLEVELAND (+150) vs. No. 1 DETROIT (-180) 
Tied 3-3

GAME 7 — CLE @ DET (May 17)

Spread: Pistons -4.5
Moneyline: Pistons -180, Cavs +150
O/U: 206.5

What to know: The Cavs and top-seeded Pistons are both headed to Game 7 for the second consecutive round. Heading into Cleveland for Game 6, down 3-2, Detroit was dominant, not losing a quarter en route to a 21-point road win. It was the Cavs' first home loss of the playoffs.

WEST SECOND ROUND

No. 4 LOS ANGELES vs. No. 1 OKLAHOMA CITY
OKC wins 4-0

No. 6 MINNESOTA vs. No. 3 SAN ANTONIO
SAS wins 4-2