Oklahoma St. 66, Texas Tech 6

Seth Doege and the Texas Tech offense couldn't keep pace with No. 2 Oklahoma State's standout quarterback. Brandon Weeden's team delivered the Red Raiders the worst loss in school history.

''Offensively today we had no rhythm,'' Texas Tech coach Tommy Tuberville said after the 66-6 home loss. ''They did a lot of good things on defense, and they did pretty much what a couple other teams did to us.''

Doege threw for a season-low 169 yards and no touchdowns, while Cowboys quarterback Weeden had five.

''Seth had a tough day, but again, he's had that on his shoulders all year long,'' Tuberville said. ''If he doesn't play well, we don't compete very well,'' Tuberville said.

Doege did not speak with the media after the game.

Weeden also threw for 423 yards and Joseph Randle ran for three more scores. The win made the Cowboys 10-0 for the first time in school history.

The Cowboys (7-0 Big 12), second in the BCS standings this week, next play at Iowa State before closing their season at home against Oklahoma in the Bedlam game. Win both, and they will likely be headed to the BCS championship game.

Weeden threw touchdown passes of 2, 27, 28, 48 and 66 yards, and had no interceptions before his backup came in late in the third quarter. Justin Blackmon and Josh Cooper each had more than 100 yards receiving.

The Cowboys dominated from the start, going up 21-0 in the first quarter. They ran at will and Weeden was sacked just once.

Stewart and Blackmon had two touchdowns each. Randle's rushing scores went for 2, 1 and 10 yards, and he finished with 78 yards on 18 carries. Herschel Sims led the Cowboys with 109 yards on 13 carries.

The Cowboys, who led the nation with 31 takeaways coming into the game, got three more against the Red Raiders.

They scored off all three first-half turnovers by Texas Tech, including a fumbled kickoff return by the Red Raiders. Ben McRoy fumbled the ball into the end zone and teammate Kenny Williams recovered it momentarily when it rolled out onto the field.

Williams lost the handle and couldn't find the ball, which eventually was recovered at the 3 and taken in for a score by Josh Stewart to make it 35-0.

About two minutes earlier, Stewart caught a 27-yard touchdown pass from Weeden to make it 21-0. He got another TD on a 66-yarder from Weeden just before the senior quarterback left the game.

It is the second time this season that the Cowboys have led by 49 points at half. Oklahoma State was up 56-7 against Kansas early last month in Stillwater.

The most points allowed by Texas Tech before Saturday came at Oklahoma in 2008 when the Red Raiders lost 65-21.

In the first half, the Red Raiders punted four times, gave up two fumbles and an interception. They have two more tries - at Missouri and at Baylor - to get a sixth win and be bowl eligible

Tech finally got on the scoreboard early in the second half on a turnover by OSU on its opening possession. Randle caught a pass from Weeden behind the line of scrimmage and Terrance Bullitt forced a fumble which Cornelius Douglas ran in from 37 yards to make it 49-6. The Red Raiders missed the extra point.