College football odds: How to bet Wyoming-Illinois

The Wyoming Cowboys will travel a thousand miles due east to take on the Illinois Fightin' Illini in a non-conference Week 0 college football game Saturday.

It will be the first football meeting between the Cowboys of the Mountain West (7-6 overall in 2021) and the Illini (5-7) of the Big Ten Conference. 

Here's everything you need from a betting perspective on the Cowboys-Illini game, from the point spread, moneyline and total over/under (odds via FOX Bet).


Wyoming @ Illinois (4 p.m. ET Saturday, Big Ten Network)

Point spread: Illinois -13.5 (Illinois favored to win by more than 13.5 points, otherwise Wyoming covers)
Moneyline: Illinois -667 favorites to win (bet $10 to win $11.50 total); Wyoming +475 underdogs to win (bet $10 to win $57.50 total)
Total scoring over/under: 42.5 points scored by both teams combined


Wyoming had quarterbacks Sean Chambers (transferred to Montana State) and Levi Williams (Utah State) entering the portal after splitting the QB duties last season. The Cowboys have yet to announce the starting QB for the Illinois game.

"With Wyoming have lost both starting quarterbacks along with other skill players to the transfer portal this offseason I feel that they will stumble out of the gate, FOX Bet trader Daniel Montanari said.

PICK: Illinois (-12.5 at FOX Bet at time of pick) to win by more than 12.5 points 


The Cowboys are coming off a 52-38 win over Kent State in the Famous Idaho Potato Bowl on Dec. 21. It was Wyoming's 17th bowl game since 1951 and fourth since 2016.

Wyoming is seeking its first win over a Big Ten school, losing its first six games.

Wyoming is 4-10 in its past 14 road games. 

The Cowboys have hit the over in the over/under (O/U) in five of its past six games.

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FOX Sports’ RJ Young breaks down which teams in the SEC will do better than their preseason win totals, and which teams will fall short. RJ is high on South Carolina and Arkansas to exceed their totals, but he believes Mississippi State will fall short of theirs. RJ also gives his best bets to put ‘Money in the Bag.’

Former Wisconsin and Arkansas head coach Bret Bielema enters his second season in charge of the Illini.

Illinois has performed well in season openers, posting a 10-1 record over the previous 11 seasons.

The Illini are 4-1 against the spread (ATS) in their past five games. 

The game against the Cowboys is Saturday, which could be good for under bettors — the Illini have hit the under in the over/under (O/U) seven times in their past nine games played on a Saturday.

Are you ready for some college football? If so, head over to FOX Bet for all your wagers.

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