Iowa vs. Northwestern Prediction, Odds, Picks For College Football Week 10

The Northwestern Wildcats kick off against the No. 19 Iowa Hawkeyes on Saturday in a Week 10 college football matchup on FOX.

Let’s take a look at the odds for Iowa vs. Northwestern at DraftKings Sportsbook as of Nov. 7.

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Moneyline

• Northwestern: +114
• Iowa: -135

Spread

• Northwestern +2.5: -115
• Iowa -2.5: -105

Over/Under

• Over 43.5: -110
• Under 43.5: -110

From FOX Sports Research: 

• Iowa has won six of their last 10, winning the last four matchups against Northwestern.
• Northwestern averages the second-most points per game in the Big Ten (33.6), trailing only Ohio State. Meanwhile, Iowa allows the second-fewest in the conference (12.5).
• Northwestern will be without quarterback Aidan Chiles, the Big Ten’s fourth-leading passer with 1,898 yards.

How to Watch No. 19 Iowa vs. Northwestern 

• Date: Saturday, Nov. 7, 2026
• Time: 7:30 p.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: Ryan Field, Evanston, IL