College football odds Week 2: How to bet Iowa State-Iowa

An interstate rivalry kicks off in Week 2.

Iowa State drives down US-30 about 130 miles to Iowa City where they will meet the University of Iowa, 4 p.m. Saturday in Kinnick Stadium.

Although Iowa won 7-3 in Week 1 against South Dakota State, they didn't get there with a touchdown. Those seven points came on two safeties and a field goal. Clearly, the Hawkeyes' defense is pretty tough, but it is the offense that will need to put some points on the board this week. Here's hoping the 69th battle for the Cy-Hawk Trophy will light the fire this offense needs.

On the other hand, Iowa State crushed Southeast Missouri State, 42-10, in their season opener. If the offense keeps clicking, they may be able to avoid their seventh straight loss in this series. Granted, the Cyclones are a rebuilding team, but with their high-powered offense and Iowa's inability to score, anything is possible.

Here's everything you need from a betting perspective in the game between the Cyclones and Hawkeyes from the point spread, moneyline, total over/under and expert pick (odds via FOX Bet).

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RELATED: Week 2 lines, odds

Iowa State @ Iowa (4 p.m. ET Saturday, Big Ten Network)

Point spread: Iowa -3.5 to win (Iowa favored to win by more than 3.5 points, otherwise Iowa State covers)
Moneyline: Iowa -189 favorite to win (bet $10 to win $15.29 total); Iowa State +145 underdog to win (bet $10 to win $24.50 total)
Total scoring over/under: 40.5 points scored by both teams combined

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Pick via FOX Sports Betting Analyst Geoff Schwartz:

I understand why you would want to avoid making a wager on Iowa after the Hawkeyes' embarrassing offensive performance last weekend against South Dakota State. Three offensive points over 60 minutes is horrendous, even for a team that is always offensively challenged. However, Iowa cannot have a worse offensive performance the entire season, and I expect their offense to bounce back against their rivals this weekend. Iowa has won this game for six consecutive years. Two of the six games fell under the 3.5 points they are giving this weekend.

The reason Iowa wins this matchup is defense. The defense for Iowa scored more points (four on two safeties) than the offense in Week 1. Other than the 2017 game where Iowa State scored 41 points, they have scored 17, 3, 3, 17 and 17 points in the other five losses.

Iowa State is going to struggle on offense as they have had a lot of turnover throughout the roster, including at quarterback and running back. This is not a game I’d expect them have success as they find their way in 2022. Iowa’s defense will swarm and overwhelm them, while Iowa’s offense will muster up more points this weekend.

PICK: Iowa (-3.5 at FOX Bet) to win by more than 3.5 points

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