2025-26 Men's First Four Odds: Spreads, Lines for all 4 Games

Eight teams highlight the first four games of the most glorious time on the sports calendar for hoops fans — the NCAA Tournament. 

Let's get into the odds for the opening contests at DraftKings Sportsbook as of March 18, as well as what to know.

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TUESDAY

No. 16 UMBC 83, No. 16 Howard 86

Spread: UMBC -1.5 (Howard covers)
O/U: 140.5 (Over hits)

No. 11 NC State 66, No. 11 Texas 68

Spread: NC State -1.5 (Texas covers)
O/U: 157.5 (Under hits)

WEDNESDAY

No. 16 Prairie View vs. No. 16 Lehigh

Spread: Lehigh -3.5
Moneyline: Lehigh -166, Prairie View +140
O/U: 142.5

What to know: Lehigh snuck into the Tournament by winning the Patriot League Tournament. Now it is favored to take down Prairie View, who snuck in by winning the SWAC Tournament. The winner will face defending champion Florida in the first round. As a favorite, Lehigh is 5-5 on the season. It has covered seven of its last nine games overall.

No. 11 Miami (OH) vs. No. 11 SMU

Spread: SMU -6.5
Moneyline: SMU -310, Miami +250
O/U: 164.5

What to know: One loss on the season, and the Redhawks are in the First Four. Fair or foul, here they are, and furthermore, they're the underdogs. As an underdog this season, Miami is 4-0 overall and ATS. SMU finished 11th in the ACC and is 8-12 ATS as the favorite. The winner will face Tennessee.