bet365 Bonus Code FOX365 Unlocks $150 for the 49ers vs Colts Monday Night Football Matchup

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The Indianapolis Colts host the San Francisco 49ers, two teams both fighting for playoff seeding and need a big win tonight. Jonathan Taylor and the Colts' offensive line look to take the pressure off the 44-year-old Philip Rivers, as he makes his second start after coming out of retirement. The Niners' have won four straight and look to keep rolling against this Colts squad.

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San Francisco Betting Info

• San Francisco has played 14 games, posting nine wins against the spread.
• The 49ers have covered the spread when playing as at least 5.5-point favorites in three of three games this season.
• San Francisco games this year have gone over the total in eight out of 14 opportunities (57.1%).
• When playing as the moneyline favorite, the 49ers are 9-1, winning 90% of the time.
• Based on this matchup's moneyline, the 49ers' implied win probability is 72.1%.

49ers Stats

San Francisco's Key Players

• Christian McCaffrey has totaled 922 rushing yards with nine touchdowns (65.9 yards per game across 14 games). His 3.6 yards per attempt rank 47th in the league. McCaffrey has been targeted 108 times in the passing game and has 86 catches (6.1 per game) for 820 yards (58.6 per game) and five TDs.
• Brock Purdy has 1,442 passing yards in six games this year, averaging 240.3 per game with a 67.9% completion percentage and 12 touchdowns against seven interceptions. He has also rushed for 87 yards (third on the 49ers) and added one touchdown on the ground, averaging 14.5 yards per game.
• Jauan Jennings has 495 receiving yards and seven touchdowns with 44 catches on 74 targets. He is averaging 3.7 receptions and 41.3 yards per game.
• Dee Winters has seven TFL and 89 tackles in 2025.
• Upton Stout has 66 tackles, four TFL, and one sack this season.
• Bryce Huff has recorded 25 tackles, six TFL, four sacks, and one pass defended.
• Ji'Ayir Brown has two interceptions while tacking on 45 tackles, one TFL, and five passes defended.

Indianapolis Betting Info

• Indianapolis has put together an 8-6-0 record against the spread this season.
• The Colts have been underdogs by 5.5 points or more once this season and covered the spread.
• Games involving Indianapolis have hit the over on seven occasions this year.
• The Colts have won two of the five games they've played as underdogs this season.
• The Colts have a 32.3% chance to win this game based on the implied probability of the moneyline.

Colts Stats

Indianapolis' Key Players

• Jonathan Taylor averages 103.1 rushing yards per game this year (1,443 total yards to rank second in the NFL), while scoring 16 rushing touchdowns. Taylor has caught 38 passes (on 44 targets) for 318 yards, with two receiving touchdowns. He's averaging 22.7 yards per game.
• Michael Pittman Jr. has 725 receiving yards and seven touchdowns on 72 receptions, while being targeted 99 times.
• Tyler Warren has caught 63 passes for 718 receiving yards with four touchdowns through the air. He has been targeted 90 total times and is averaging 4.5 receptions per game over 14 games played.
• Alec Pierce has 785 receiving yards and two touchdowns from 39 receptions after getting 68 targets.
• Germaine Pratt has six TFL and 108 tackles through 13 games in 2025.
• Zaire Franklin has two sacks in addition to his five TFL and 104 tackles through 14 games.
• Nick Cross has 2.5 sacks in addition to his four TFL, 95 tackles, and one interception.
• Laiatu Latu's stat sheet includes three interceptions as well as 38 tackles, 10 TFL, 6.5 sacks, and four passes defended in 13 games

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